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KMID : 0603820070130040313
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Journal of Experimental & Biomedical Science
2007 Volume.13 No. 4 p.313 ~ p.317
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Effect of Ailanthi Radicis Cortex Extracts on Melanogenesis
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Cho Young-Ho
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Abstract
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Melanogenesis refers to the biosynthesis of melanin pigment in melanocytes. Melanogenesis is controlled by the intra- and extracellular environments. In the present study, to develop a new whitening agent, it was investigated the antioxidant activity and the inhibitory effect of Ailanthi Radicis Cortex extract on tyrosinase activity and on melanogenesis in the B16/F1 melanoma cells. The inhibition ratio of tyrosinase activity of ethylacetate fraction from Ailanthi Radicis Cortex was higher than that of arbutin. The ethylacetate fraction showed scavenging activities of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and superoxide anion radicals in a dose dependent manner. The highest inhibitory activity of melanogenesis was also in ethylacetate fraction (40.0{pm}5% at the concentration of 400{mu}g/ml). This study demonstrates that the Ailanthi Radicis Cortex extract might be used to be a potential agent for skin whitening.
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KEYWORD
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Ailanthi radicis Cortex, Antioxidant, Melanogenesis, Tyrosinase
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